Ajoene

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物,专注于信号通路和疾病研究领域。
Ajoene 

Ajoene 是一种大蒜衍生化合物,是一种抗血栓和抗真菌剂。Ajoene 抑制HL-60、U937、HEL 和 OCIM-I 等白血病 CD34 阴性细胞的增殖并诱导其凋亡。具有抗癌活性。

Ajoene

Ajoene Chemical Structure

CAS No. : 92285-01-3

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Ajoene 相关产品

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同靶点蛋白产品:

生物活性

Ajoene, a garlic-derived compound, is an antithrombotic and antifungal agent. Ajoene inhibits proliferation and induces apoptosis of human leukaemia CD34-negative cells including HL-60, U937, HEL and OCIM-I. Anticancer activities[1][2].

体外研究
(In Vitro)

Ajoene shows cytotoxicity with IC50s in the 7-41 uM range for B16/BL6, HT-29, A549, MDA-MB231, PANC-1, and SKBR-3 cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Ajoene 相关抗体:

体内研究
(In Vivo)

Ajoene (25 μg/g body weight of Ajoene in 100 mL Intralipid; i.p.; every other day from the day of inoculation up to day 28) inhibits both primary tumor growth[1].
Ajoene (25, 15 or 5 μg/g body weight of Ajoene in 100 μL Intralipid; i.p; every other day over 4 weeks) inhibits strongly metastasis to lung in the B16/BL6 melanoma tumor model in C57BL/6 mice[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

234.40

Formula

C9H14OS3

CAS 号

92285-01-3

性状

液体

颜色

Colorless to light yellow

结构分类
  • Others
初始来源
  • 植物
  • 百合科
  • 大蒜
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Solution, -20°C, 2 years

纯度 & 产品资料

纯度: ≥99.0%

Data Sheet (524 KB) SDS (251 KB)

COA (256 KB)

产品使用指南 (1538 KB)

参考文献
  • [1]. Taylor P, et al. Ajoene inhibits both primary tumor growth and metastasis of B16/BL6 melanoma cells in C57BL/6 mice. Cancer Lett. 2006;239(2):298-304.  [Content Brief]

    [2]. Ahmed N, et al. Ajoene, a garlic-derived natural compound, enhances chemotherapy-induced apoptosis in human myeloid leukaemia CD34-positive resistant cells. Anticancer Res. 2001;21(5):3519-3523.  [Content Brief]

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