Phellamurin

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物,专注于信号通路和疾病研究领域。
Phellamurin 

Phellamurin 是一种来自 Phellodendron amurense 叶的植物黄酮糖苷,可抑制肠道 P-糖蛋白 (P-glycoprotein)。Phellamurin 还抑制凤蝶的产卵。Phellamurin 诱导细胞凋亡 (apoptosis),并具有抗肿瘤活性。

Phellamurin

Phellamurin Chemical Structure

CAS No. : 52589-11-4

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1 mg ¥2446 1 周
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Phellamurin 相关产品

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生物活性

Phellamurin is a plant flavonone glycoside from the leaves of Phellodendron amurense and inhibits intestinal P-glycoprotein. Phellamurin also inhibits egg laying by Papilio protenor. Phellamurin induces cells apoptosis and has anti-tumor activity[1][2][3].

体外研究
(In Vitro)

Phellamurin (0-10 μg/mL; 48 hours; U2OS and Saos-2 cells) treatment leads to a repression of cell viability in U2OS and Saos-2 cells in a dose-dependent manner[1].
Phellamurin (0-10 μg/mL; 48 hours; U2OS and Saos-2 cells) treatment concentration-dependently promots the apoptosis of U2OS and Saos-2 cells[1].
Phellamurin (0-10 μg/mL; 48 hours; U2OS and Saos-2 cells) treatment declines the ratios of p-PI3K/PI3K, p-AKT/AKT, and p-mTOR/mTOR in U2OS and Saos-2 cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Phellamurin 相关抗体:

Cell Viability Assay[1]

Cell Line: U2OS and Saos-2 cells
Concentration: 0 μg/mL, 2.5 μg/mL, 5 μg/mL, and 10 μg/mL
Incubation Time: 48 hours
Result: Suppressed the viability of U2OS and Saos-2 cells in a concentration-dependent manner.

Apoptosis Analysis[1]

Cell Line: U2OS and Saos-2 cells
Concentration: 0 μg/mL, 2.5 μg/mL, 5 μg/mL, and 10 μg/mL
Incubation Time: 48 hours
Result: Induced apoptosis of U2OS and Saos-2 cells in a concentration-dependent manner.

Western Blot Analysis[1]

Cell Line: U2OS and Saos-2 cells
Concentration: 0 μg/mL and 10 μg/mL
Incubation Time: 48 hours
Result: Repressed the PI3K/AKT/mTOR pathway in U2OS and Saos-2 cells.

体内研究
(In Vivo)

Phellamurin (50 mg/kg/day; intraperitoneal injection; daily; for 21 days; female BALB/c nude mice) treatment represses osteosarcoma tumor growth in vivo. The ratios of p-PI3K/PI3K, p-AKT/AKT, and p-mTOR/mTOR are decreased in xenograft in Phellamurin-treated mice[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Athymic female BALB/c nude mice (6 weeks old ) injected with U2OS cells[1]
Dosage: 50 mg/kg/day
Administration: Intraperitoneal injection; daily; for 21 days
Result: Repressed osteosarcoma tumor growth in vivo.

分子量

518.51

Formula

C26H30O11

CAS 号

52589-11-4

性状

固体

颜色

Light yellow to yellow

结构分类
  • Flavonoids
  • Flavanonols
  • Phenols
  • Polyphenols
初始来源
  • 植物
  • 芸香科
  • 黄柏
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: ≥96.0%

Data Sheet (534 KB) SDS (392 KB)

COA (265 KB) HNMR (131 KB)

产品使用指南 (1538 KB)

参考文献
  • [1]. Hongzhi Zhang, et al. Anti-tumor Efficacy of Phellamurin in Osteosarcoma Cells: Involvement of the PI3K/AKT/mTOR Pathway. Eur J Pharmacol. 2019 Sep 5;858:172477.  [Content Brief]

    [2]. Hung-Yi Chen, et al. Marked Decrease of Cyclosporin Absorption Caused by Phellamurin in Rats. Planta Med. 2002 Feb;68(2):138-41.  [Content Brief]

    [3]. Keiichi Honda, et al. Synergistic or Antagonistic Modulation of Oviposition Response of Two Swallowtail Butterflies, Papilio Maackii and P. Protenor, to Phellodendron Amurense by Its Constitutive Prenylated Flavonoid, Phellamurin. J Chem Ecol. 2011 Jun;37(6):575-81.  [Content Brief]

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