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Phellamurin
Phellamurin 是一种来自 Phellodendron amurense 叶的植物黄酮糖苷,可抑制肠道 P-糖蛋白 (P-glycoprotein)。Phellamurin 还抑制凤蝶的产卵。Phellamurin 诱导细胞凋亡 (apoptosis),并具有抗肿瘤活性。
Phellamurin Chemical Structure
CAS No. : 52589-11-4
规格 | 价格 | 是否有货 | 数量 |
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1 mg | ¥2446 | 1 周 | |
5 mg | 询价 | ||
10 mg | 询价 |
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生物活性 |
Phellamurin is a plant flavonone glycoside from the leaves of Phellodendron amurense and inhibits intestinal P-glycoprotein. Phellamurin also inhibits egg laying by Papilio protenor. Phellamurin induces cells apoptosis and has anti-tumor activity[1][2][3]. |
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体外研究 (In Vitro) |
Phellamurin (0-10 μg/mL; 48 hours; U2OS and Saos-2 cells) treatment leads to a repression of cell viability in U2OS and Saos-2 cells in a dose-dependent manner[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability Assay[1]
Apoptosis Analysis[1]
Western Blot Analysis[1]
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体内研究 (In Vivo) |
Phellamurin (50 mg/kg/day; intraperitoneal injection; daily; for 21 days; female BALB/c nude mice) treatment represses osteosarcoma tumor growth in vivo. The ratios of p-PI3K/PI3K, p-AKT/AKT, and p-mTOR/mTOR are decreased in xenograft in Phellamurin-treated mice[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
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分子量 |
518.51 |
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Formula |
C26H30O11 |
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CAS 号 |
52589-11-4 |
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性状 |
固体 |
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颜色 |
Light yellow to yellow |
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结构分类 |
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初始来源 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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纯度 & 产品资料 |
纯度: ≥96.0%
Data Sheet (534 KB) SDS (392 KB)
COA (265 KB) HNMR (131 KB) 产品使用指南 (1538 KB) |
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参考文献 |
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