Moracin P (Synonyms: 桑辛素P)

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Moracin P  (Synonyms: 桑辛素P) 纯度: 99.57%

Moracin P 是从 Mori Cortex Radicis 中分离出来的 2-芳基苯并呋喃。Moracin P 对缺氧诱导因子 (HIF-1) 表现出强大的体外抑制活性。Moracin P 减少了氧葡萄糖剥夺 (OGD) 诱导的活性氧 (ROS) 的产生。Moracin P 具有神经保护和抗炎作用。

Moracin P (Synonyms: 桑辛素P)

Moracin P Chemical Structure

CAS No. : 102841-46-3

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1 mg ￥1200 In-stock
5 mg ￥2800 In-stock
10 mg ￥4500 In-stock
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Moracin P 相关产品

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生物活性

Moracin P is a 2-arylbenzofuran isolated from the Mori Cortex Radicis. Moracin P exhibits potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1). Moracin P reduces oxygen-glucose deprivation (OGD)-induced reactive oxygen species (ROS) production. Moracin P has neuroprotective and anti-inflammatory effects[1][2][3].

体外研究
(In Vitro)

Moracin P enhances cell viability in dose-dependent manner against oxygen-glucose deprivation (OGD)-induced cell death in neuroblastoma SH-SY5Y cells with an EC50 value of 10.4 μM. Moracin P reduces ROS production in OGD-induced cell death (IC50 values of 1.9 μM). Consequently, reactive oxygen species (ROS) are overexpressed in OGD-induced cells and Moracin P reduces ROS induced by OGD in dosedependent manner[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Moracin P 相关抗体:
分子量

326.34

Formula

C19H18O5
CAS 号

102841-46-3
性状

固体

颜色

White to off-white

中文名称

桑辛素P
结构分类
  • Phenols
  • Polyphenols
初始来源
  • 植物
  • 其他科
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料

纯度: 99.57%

Data Sheet (531 KB) SDS (393 KB)

COA (170 KB) HNMR (222 KB) CNMR (211 KB) RP-HPLC (228 KB) MS (601 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Hak Ju Lee, et al. Inhibitory effect of 2-arylbenzofurans from the Mori Cortex Radicis (Moraceae) on oxygen glucose deprivation (OGD)-induced cell death of SH-SY5Y cells. Arch Pharm Res. 2011 Aug;34(8):1373-80.  [Content Brief]

    [2]. Yan Xia, et al. HIF-1α inhibitors: synthesis and biological evaluation of novel moracin O and P analogues. Eur J Med Chem. 2011 Jun;46(6):2386-96.  [Content Brief]

    [3]. Besse Hardianti, et al. Anti-inflammatory compounds moracin O and P from Morus alba Linn. (Sohakuhi) target the NF‑κB pathway. Mol Med Rep. 2020 Dec;22(6):5385-5391.  [Content Brief]

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