K-252c

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物,专注于信号通路和疾病研究领域。
K-252c  纯度: ≥99.0%

K-252c,一种十字孢碱的类似物,可从Nocardiopsis sp.中分离得到,是一种能透过细胞的、PKC 的抑制剂,IC50 值为2.45 µM。K-252c可诱导人慢性粒细胞白血病癌细胞凋亡。K-252c还能抑制β内酰胺酶、胰凝乳蛋白酶和苹果酸脱氢酶。

K-252c

K-252c Chemical Structure

CAS No. : 85753-43-1

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生物活性

K-252c, a staurosporine analog isolated from Nocardiopsis sp., is a cell-permeable PKC inhibitor, with an IC50 of 2.45 µM. K-252c induces apoptosis in human chronic myelogenous leukemia cancer cells. K-252c also inhibits β-lactamase, chymotrypsin, and malate dehydrogenase[1][2][3].

IC50 & Target

IC50: 2.45 µM (PKC)[1].

分子量

311.34

Formula

C20H13N3O

CAS 号

85753-43-1

性状

固体

颜色

White to off-white

结构分类
  • Alkaloids
  • Indole Alkaloids
初始来源
  • 微生物

Nocardiopsis sp.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料

纯度: ≥99.0%

Data Sheet (539 KB) SDS (251 KB)

COA (272 KB)

产品使用指南 (1538 KB)

参考文献
  • [1]. Pereira, E.R., et al. Structure-activity relationships in a series of substituted indolocarbazoles: Topoisomerase I and protein kinase C inhibition and antitumoral and antimicrobial properties J. Med. Chem. 39(22), 4471-4477 (1996).  [Content Brief]

    [2]. Liu, R., et al. Two indolocarbazole alkaloids with apoptosis activity from a marine-derived actinomycete Z2039-2 Arch. Pharm. Res. 30(3), 270-274 (2007).  [Content Brief]

    [3]. Zimmermann, A., et al. Indolocarbazoles exhibit strong antiviral activity against human cytomegalovirus and are potent inhibitors of the pUL97 protein kinase Antiviral Res. 48(1), 49-60 (2000).  [Content Brief]

    [4]. McGovern, S.L., et al. Kinase inhibitors: Not just for kinases anymore Journal of Medicinal Chemistry 46, 1478-1483 (2003).  [Content Brief]

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