N-methyl-N-dithiocarboxyglucamine (Synonyms: MDCG)

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N-methyl-N-dithiocarboxyglucamine (Synonyms: MDCG)

N-methyl-N-dithiocarboxyglucamine (MDCG) 能够动员和促进金属硫蛋白结合的 ¹⁰⁹Cd 的排泄。N-methyl-N-dithiocarboxyglucamine 对急性和慢性镉中毒均有效。

N-methyl-N-dithiocarboxyglucamine Chemical Structure

CAS No. : 94161-07-6

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N-methyl-N-dithiocarboxyglucamine 的其他形式现货产品:

N-methyl-N-dithiocarboxyglucamine sodium

N-methyl-N-dithiocarboxyglucamine 相关产品

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•同靶点蛋白产品:

生物活性

N-methyl-N-dithiocarboxyglucamine (MDCG) mobilizes and promotes excretion of metallothione-bound ¹⁰⁹Cd. N-methyl-N-dithiocarboxyglucamine shows effects on acute and chronic Cd intoxication^[1].

体内研究
(In Vivo)

N-methyl-N-dithiocarboxyglucamine (684-2736 mg/kg；腹腔注射，每日注射 3 次) 3 天内有效促进粪便镉排泄^[1]。
N-methyl-N-dithiocarboxyglucamine (2736 mg/kg；腹腔注射，每周注射 3 次) 降低肾脏和肝脏的镉水平^[1]。

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Mice with CdCl₂ injection^[1]
Dosage:	684, 1368 and 2736 mg/kg
Administration:	Intraperitoneal injection; 684, 1368 and 2736 mg/kg, three daily injection
Result:	Dose-dependently increased fecal Cd excretion and caused a fecal Cd excretion of almost 30% of the administered Cd over a 3-day period at a dose of 2736 mg/kg.

分子量

271.35

Formula

C₈H₁₇NO₅S₂

CAS 号

94161-07-6

结构分类

Others

初始来源

内源性代谢物

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料

Data Sheet (525 KB) 产品使用指南 (1538 KB)

参考文献

[1]. Gale GR, et al. Effects of sodium N-methyl-N-dithiocarboxyglucamine on cadmium distribution and excretion. Life Sci. 1984 Dec 17;35(25):2571-8. [Content Brief]

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