Sodium taurodeoxycholate hydrate (Synonyms: 牛磺脱氧胆酸钠水合物)

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Sodium taurodeoxycholate hydrate  (Synonyms: 牛磺脱氧胆酸钠水合物) 纯度: ≥97.0%

Sodium taurodeoxycholate hydrate 是一种胆汁酸，是由肝脏中的胆固醇合成的两亲性表面活性剂分子。 除 TGR5 通路外，Sodium taurodeoxycholate hydrate 还激活 S1PR2 通路。

Sodium taurodeoxycholate hydrate (Synonyms: 牛磺脱氧胆酸钠水合物)

Sodium taurodeoxycholate hydrate Chemical Structure

CAS No. : 207737-97-1

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500 mg ￥500 In-stock
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生物活性

Sodium taurodeoxycholate hydrate, a bile acid, is an amphiphilic surfactant molecule synthesized from cholesterol in the liver. Sodium taurodeoxycholate hydrate activates the S1PR2 pathway in addition to the TGR5 pathway[1].

IC50 & Target

Microbial Metabolite

 

体外研究
(In Vitro)

The median plasma concentration of Taurodeoxycholate is 33.9 nM in healthy individuals[1].
Taurodeoxycholate inhibits the binding of N-3H-methylscopolamine to the M3 muscarinic receptor of acetylcholine with an IC50 of 170 µM[1].
Taurodeoxycholate (0.05-1.00 mM; 1-6 days) stimulates intestinal epithelial cell proliferation[2].
Taurodeoxycholate (0.05-1.00 mM; 24 h) induces a significant increase in S-phase concentration and a significant decrease in G1-phase concentration of the cell cycle, increases c-myc protein and mRNA expression in IEC-6 cells[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Sodium taurodeoxycholate hydrate 相关抗体:

Cell Proliferation Assay[2]

Cell Line: IEC-6 and caco-2 cells
Concentration: 0, 0.05, 0.50, and 1.00 mM
Incubation Time: 1, 2, 4 and 6 days
Result: Significantly stimulated intestinal epithelial cell proliferation in a dose-dependent manner.

Cell Cycle Analysis[2]

Cell Line: IEC-6 cells
Concentration: 0, 0.05, 0.50, and 1.00 mM
Incubation Time: 24 h
Result: Significantly increased cells in S phase and decreased cells in G1-phase.

Western Blot Analysis[2]

Cell Line: IEC-6 cells
Concentration: 0.5 mM
Incubation Time: 1 and 6 days
Result: Significantly increased c-myc protein expression.

体内研究
(In Vivo)

Taurodeoxycholate (0.5 mg/kg; i.v.; once) confers protection to C57BL/6N mice with sepsis, but does not protect TGR5 KO mice under sepsis[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6N mice, Lipopolysaccharides (HY-D1056) injection model of sepsis[1]
Dosage: 0.5 mg/kg
Administration: Intravenous injection, 30 min or 24 h after LPS injection
Result: Improved the survival rate of mice with sepsis. Decreased liver and kidney damage in septic mice. Ameliorated systemic inflammation and normalized blood pressure in septic mice.

分子量

521.69

Formula

C26H44NNaO6S
CAS 号

207737-97-1
性状

固体

颜色

White to off-white

中文名称

牛磺脱氧胆酸钠水合物
结构分类
  • Steroids
初始来源
  • 内源性代谢物
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

H2O 中的溶解度 : 100 mg/mL (191.68 mM; 超声助溶)

DMSO 中的溶解度 : 100 mg/mL (191.68 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.9168 mL 9.5842 mL 19.1685 mL
5 mM 0.3834 mL 1.9168 mL 3.8337 mL
10 mM 0.1917 mL 0.9584 mL 1.9168 mL

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储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

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纯度 & 产品资料

纯度: ≥97.0%

Data Sheet (605 KB) SDS (393 KB)

COA (196 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Chang S, et al. Taurodeoxycholate Increases the Number of Myeloid-Derived Suppressor Cells That Ameliorate Sepsis in Mice. Front Immunol. 2018 Sep 18;9:1984.  [Content Brief]

    [2]. Yamaguchi J, et al. Taurodeoxycholate increases intestinal epithelial cell proliferation through c-myc expression. Surgery. 2004 Feb;135(2):215-21.  [Content Brief]

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