标签归档：磷酸

6-Phosphogluconic acid (Synonyms: 6-磷酸葡萄糖酸)

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6-Phosphogluconic acid  (Synonyms: 6-磷酸葡萄糖酸)

6-Phosphogluconic acid 是一种有效的，竞争性磷酸葡萄糖异构酶 (PGI) 抑制剂，对 6-磷酸葡萄糖和 6-磷酸果糖的 Ki 值分别为 48 μM 和 42 μM。6-Phosphogluconic acid 是一种内源性代谢物 (endogenous metabolite)。

6-Phosphogluconic acid (Synonyms: 6-磷酸葡萄糖酸)

6-Phosphogluconic acid Chemical Structure

CAS No. : 921-62-0

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6-Phosphogluconic acid 的其他形式现货产品:

6-Phosphogluconic acid trisodium

6-Phosphogluconic acid 相关产品

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•同靶点蛋白产品:

生物活性

6-Phosphogluconic acid is a potent and competitive phosphoglucose isomerase (PGI) inhibitor with Kis of 48 μM for glucose 6-phosphate and 42 μM for fructose 6-phosphate. 6-Phosphogluconic acid is an endogenous metabolite[1][2].

IC50 & Target[1][2]

Human Endogenous Metabolite

 

体外研究
(In Vitro)

6-Phosphogluconic acid (0.5-2.0 mM) completely inhibits the activity of PGI with glucose 6-phosphate (0.05- 0.5 mM) as the substrate[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

6-Phosphogluconic acid 相关抗体:
分子量

276.14

Formula

C6H13O10P
CAS 号

921-62-0
中文名称

6-磷酸葡萄糖酸
结构分类
  • Others
初始来源
  • 内源性代谢物
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (528 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Gaitonde MK, et al. Effect of 6-phosphogluconate on phosphoglucose isomerase in rat brain in vitro and in vivo. J Neurochem. 1989 May;52(5):1348-52.  [Content Brief]

    [2]. Hitosugi T, et al. Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth. Cancer Cell. 2012 Nov 13;22(5):585-600.  [Content Brief]

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