Cyclosporin A-d4(Synonyms: Cyclosporine A-d4; Ciclosporin A-d4; CsA-d4)

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Cyclosporin A-d4 (Synonyms: Cyclosporine A-d4; Ciclosporin A-d4; CsA-d4)

Cyclosporin A-d4 是 Cyclosporin A 的氘代物。 Cyclosporin A (Cyclosporine A) 是一种免疫抑制剂，能与亲环素结合，抑制 calcineurin 活性的IC50 值为 7 nM。Cyclosporin A 也抑制 CD11a/CD18 粘附分子。

Cyclosporin A-d4(Synonyms: Cyclosporine A-d4; Ciclosporin A-d4; CsA-d4)

Cyclosporin A-d4 Chemical Structure

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生物活性

Cyclosporin A-d4 is the deuterium labeled Cyclosporin A. Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of calcineurin with an IC50 of 5 nM. Cyclosporin A also inhibits CD11a/CD18 ad

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1206.64

Formula

C62H107D4N11O12
中文名称

环孢霉素A d4；环孢素A d4；环孢多肽A d4；环孢灵 d4；赛斯平 d4；环孢素 d4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

    [2]. Handschumacher RE, et al. Cyclophilin: a specific cytosolic binding protein for cyclosporin A. Science. 1984 Nov 2;226(4674):544-7.;Liu J, et al. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell. 1991 Aug 23;66(4)

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