Chloramphenicol-d4

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Chloramphenicol-d4 

Chloramphenicol-d4 是 Chloramphenicol 氘代物。Chloramphenicol 是一种 (bacterial) 感染的广谱抗生素，作为细菌蛋白质生物合成的有效抑制剂。Chloramphenicol 主要作用于细菌 70S 核糖体的 50S 亚基，通过抑制肽基转移酶活性来抑制肽键的形成。

Chloramphenicol-d4

Chloramphenicol-d4 Chemical Structure

规格 是否有货
1 mg 询价
5 mg 询价

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生物活性

Chloramphenicol-d4 is deuterium labeled Chloramphenicol. Chloramphenicol, a broad-spectrum antibiotic, acts as a potent inhibitor of bacterial protein biosynthesis[1][2]. Chloramphenicol acts primarily on the 50S subunit of bacterial 70S rihosomes and inhibits peptide bond formation by suppressing peptidyl transferase activity[3].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

327.15

Formula

C11H8D4Cl2N2O5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Jardetzky, O., Studies on the mechanism of action of chloramphenicol. I. The conformation of chlioramphenicol in solution. J Biol Chem, 1963. 238: p. 2498-508.

    [3]. Polikanov YS, et al. The Mechanisms of Action of Ribosome-Targeting Peptide Antibiotics. Front Mol Biosci. 2018;5:48. Published 2018 May 14.

    [4]. Bartlett JG. Chloramphenicol. Med Clin North Am. 1982;66(1):91-102.

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