Methyldopa-d3 hydrochloride(Synonyms: L-(-)-α-Methyldopa-d3 hydrochloride; MK-351-d3 hydrochloride)

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Methyldopa-d3 hydrochloride (Synonyms: L-(-)-α-Methyldopa-d3 hydrochloride; MK-351-d3 hydrochloride)

Methyldopa-d3 (hydrochloride) 是 Methyldopa (hydrochloride) 氘代物。Methyldopa hydrochloride (L-(-)-α-Methyldopa hydrochloride) 是一种 α-肾上腺素能激动剂（对 α2-adrenergic receptors 有选择性）。Methyldopa hydrochloride 是一种前药，在中枢神经系统中被代谢 (α-Methylepinephrine)。

Methyldopa-d3 hydrochloride(Synonyms: L-(-)-α-Methyldopa-d3 hydrochloride; MK-351-d3 hydrochloride)

Methyldopa-d3 hydrochloride Chemical Structure

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生物活性

Methyldopa-d3 (hydrochloride) is deuterium labeled Methyldopa (hydrochloride). Methyldopa hydrochloride (L-(-)-α-Methyldopa hydrochloride) hydrochloride, a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopa hydrochloride is a prodrug and is metabolized (α-Methylepinephrine) in the central nervous system[1][2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

250.69

Formula

C10H11D3ClNO4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Sweet CS. New centrally acting antihypertensive drugs related to methyldopa and clonidine. Hypertension. 1984;6(5 Pt 2):II51-II56.

    [3]. Fox GR, et al. The effects of phenobarbital, atropine, L-alpha-methyldopa, and DL-propranolol on dieldrin-induced hyperglycemia in the adult rat. Toxicol Appl Pharmacol. 1985;78(3):342-350.

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