Oxyphenbutazone(Synonyms: 羟布宗)

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Oxyphenbutazone (Synonyms: 羟布宗) 纯度: ≥99.0%

Oxyphenbutazone 是一种苯丁酮衍生物，具有抗炎作用。Oxyphenbutazone 是一种非选择性的 COX 抑制剂。Oxyphenbutazone 是保泰松 (Phenylbutazone; HY-B0230) 的代谢物。Oxyphenbutazone 能选择性地杀死不复制的结核分枝杆菌 (Mycobaterium tuberculosis)。

Oxyphenbutazone(Synonyms: 羟布宗)

Oxyphenbutazone Chemical Structure

CAS No. : 129-20-4

规格 价格 是否有货 数量
10 mg ￥2300 询价
25 mg ￥3650 询价
50 mg ￥6000 询价
100 mg   询价  
200 mg   询价  

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生物活性

Oxyphenbutazone is a phenylbutazone derivative, with anti-inflammatory effect. Oxyphenbutazone is a non-selective COX inhibitor. Oxyphenbutazone is the metabolite of Phenylbutazone (HY-B0230). Oxyphenbutazone selectively kills non-replicating Mycobaterium tuberculosis[1][2].

IC50 & Target

COX[1]
体外研究
(In Vitro)

Oxyphenbutazone enhances the anticancer efficiency of Methotrexate (MTX) (HY-14519) in Hep3B cells[1].
Oxyphenbutazone (2.5-7.5 µM; 48 hours) co-treatment with (MTX, 0.25-1.0 µM) shows potential cytotoxicity against Hep3B cells[1].
Oxyphenbutazone exhibits reparative effects in the hepatocytes[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[1]

Cell Line: Hep3B cells
Concentration: 2.5 µM, 5 µM, 7.5 µM
Incubation Time: 48 hours
Result: Enhanced the cytotoxicity of MTX.

体内研究
(In Vivo)

Oxyphenbutazone (70 mg/kg/week; p.o.; in two divided doses; for 13 weeks) exerts potential anticancer activity when co-treatment with MTX (5.0 or 2.5 mg/kg/week; i.p.)[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar strain albino male rats (5-6 weeks; 150-220 g)[1]
Dosage: 70 mg/kg/week (co-treatment with MTX 5.0 or 2.5 mg/kg/week)
Administration: PO; once a week; in two divided doses; for 13 weeks
Result: Exerted potential anticancer activity in rats when co-treatment with MTX.

分子量

324.37

Formula

C19H20N2O3
CAS 号

129-20-4
中文名称

羟布宗
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
参考文献

  • [1]. Saleem S, et al. Oxyphenbutazone promotes cytotoxicity in rats and Hep3B cellsvia suppression of PGE2 and deactivation of Wnt/β-catenin signaling pathway. Mol Cell Biochem. 2018 Jul;444(1-2):187-196.

    [2]. Gold B, et al. Nonsteroidal anti-inflammatory drug sensitizes Mycobacterium tuberculosis to endogenous and exogenous antimicrobials. Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16004-11.

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