Dehydroaripiprazole-d8(Synonyms: OPC-14857-d8; DM-14857-d8)

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Dehydroaripiprazole-d8 (Synonyms: OPC-14857-d8; DM-14857-d8)

Dehydroaripiprazole-d8 是 Dehydroaripiprazole 氘代物。Dehydroaripiprazole (OPC-14857) 是 Aripiprazole 的活性代谢产物。Aripiprazole 是一种抗精神病药，被 CYP3A4 和 CYP2D6 代谢，主要形成 Dehydroaripiprazole。Dehydroaripiprazole 具有与 Aripiprazole 同等的抗精神病活性。

Dehydroaripiprazole-d8(Synonyms: OPC-14857-d8; DM-14857-d8)

Dehydroaripiprazole-d8 Chemical Structure

CAS No. : 2749328-53-6

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生物活性

Dehydroaripiprazole-d8 is deuterium labeled Dehydroaripiprazole. Dehydroaripiprazole (OPC-14857) is an active metabolite of Aripiprazole. Aripiprazole is an antipsychotic agent and is metabolized by CYP3A4 and CYP2D6 forming mainly Dehydroaripiprazole. Dehydroaripiprazole has with antipsychotic activity equivalent to Aripiprazole[1][2][3].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

454.42

Formula

C23H17D8Cl2N3O2
CAS 号

2749328-53-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Kirschbaum KM, et al. Serum levels of aripiprazole and dehydroaripiprazole, clinical response and side effects. World J Biol Psychiatry. 2008;9(3):212-8.

    [3]. Lin SK, et al. Aripiprazole and dehydroaripiprazole plasma concentrations and clinical responses in patients with schizophrenia. J Clin Psychopharmacol. 2011 Dec;31(6):758-62.

    [4]. Hui-ChingHuang, et al. Detection and quantification of aripiprazole and its metabolite, dehydroaripiprazole, by gas chromatography–mass spectrometry in blood samples of psychiatric patients. Journal of Chromatography B. Volume 856, Issues 1-2, 1 September 2007, Pages 57-61.

    [5]. Stip E, Tourjman V. et al. Aripiprazole in schizophrenia and schizoaffective disorder: A review. Clin Ther. 2010;32 Suppl 1:S3-20.

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