Ercalcitriol-13C,d3(Synonyms: 1α,25-Dihydroxy Vitamin D2-13C,d3)

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Ercalcitriol-13C,d3 (Synonyms: 1α,25-Dihydroxy Vitamin D2-13C,d3)

Ercalcitriol-13C,d3 是一种 13C- 和氘代标记的 Ercalcitriol。Ercalcitriol (1α,25-Dihydroxy Vitamin D2)是维生素D2活性代谢物。

Ercalcitriol-13C,d3(Synonyms: 1α,25-Dihydroxy Vitamin D2-13C,d3)

Ercalcitriol-13C,d3 Chemical Structure

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生物活性

Ercalcitriol-13C,d3 is the 13C- and deuterium labeled. Ercalcitriol (1α,25-Dihydroxy Vitamin D2) is an active metabolite of vitamin D2.

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[48].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

432.66

Formula

C2713CH41D3O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223.

    [2]. Mawer EB, Berry JL, Cundall JP, Still PE, White A.A sensitive radioimmunoassay using a monoclonal antibody that is equipotent for ercalcitriol and calcitriol (1,25-dihydroxy vitamin D2 and D3).Clin Chim Acta. 1990 Oct 15;190(3):199-209.

    [3]. Rambeck et al (1984) Biological activity of 1 alpha,25-dihydroxyergocalciferol in rachitic chicks and in rats. Int.J.Vitamin.Nutr.Res. 54 135.

    [4]. Shamik J. Parikh, Marni Edelman, Gabriel I. Uwaifo et al. The Relationship between Obesity and Serum 1,25-Dihydroxy Vitamin D Concentrations in Healthy Adults. The Journal of Clinical Endocrinology & Metabolism March 1, 2004 vol. 89 no. 3 1196-1199

    [5]. Daniel W. Coyne, Marvin Grieff, Shubhada N. Ahya et al. Differential effects of acute administration of 19-Nor-1,25-dihydroxy-vitamin D2 and 1,25-dihydroxy-vitamin D3 on serum calcium and phosphorus in hemodialysis patients. American Journal of Kidney Diseases. December 2002,Volume 40, Issue 6 , Pages 1283-1288

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