Imazamox-13C,d3(Synonyms: CL29926-13C,d3; (±)-Imazamox-13C,d3)

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Imazamox-13C,d3 (Synonyms: CL29926-13C,d3; (±)-Imazamox-13C,d3)

Imazamox-13C,d3 是一种 13C- 和氘代标记的 Imazamox。Imazamox (CL29926) 是一种全身性除草剂，具有高选择性，高活性，安全性和广谱活性，可抑制植物中乙酰乳酸合酶(ALS) 的产生，进而抑制植物生长并最终导致植物死亡。

Imazamox-13C,d3(Synonyms: CL29926-13C,d3; (±)-Imazamox-13C,d3)

Imazamox-13C,d3 Chemical Structure

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生物活性

Imazamox-13C,d3 is the 13C- and deuterium labeled. Imazamox (CL29926) is a systemic herbicide that inhibits the production of acetolactate synthase (ALS) in plants with high selectivity, high activity, safety and broadspectrum activity, which would then inhibit plant growth and ultimately lead to plant death[1][2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[91].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

309.34

Formula

C1413CH16D3N3O4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223.

    [2]. García-Garijo A, et al. Metabolic responses in root nodules of Phaseolus vulgaris and Vicia sativa exposed to the imazamox herbicide. Pestic Biochem Physiol. 2014 May;111:19-23.

    [3]. Wei J et al. Enantioselective Phytotoxicity of Imazamox Against Maize Seedlings. Bull Environ Contam Toxicol. 2016 Feb;96(2):242-7.

    [4]. Imazamox Chemical Fact Sheet. Wisconsin Department of Natural Resources. DNR PUB-WT-974 2012.

    [5]. Sevim Ç, et al. An imazamox-based herbicide causes apoptotic changes in rat liver and pancreas. Toxicol Rep. 2018 Nov 19;6:42-50.

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