Diphenhydramine-d6 hydrochloride(Synonyms: 盐酸苯海拉明 d6 (盐酸盐))

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Diphenhydramine-d6 hydrochloride (Synonyms: 盐酸苯海拉明 d6 (盐酸盐))

Diphenhydramine-d6 hydrochloride 是 Diphenhydramine hydrochloride 的氘代物。Diphenhydramine hydrochloride 是第一代具有抗胆碱能作用的组胺 H1 受体 (histamine H1-receptor) 拮抗剂。Diphenhydramine hydrochloride 能透过血脑屏障。

Diphenhydramine-d6 hydrochloride(Synonyms: 盐酸苯海拉明 d6 (盐酸盐))

Diphenhydramine-d6 hydrochloride Chemical Structure

CAS No. : 1189986-72-8

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生物活性

Diphenhydramine-d6 hydrochloride is the deuterium labeled Diphenhydramine hydrochloride. Diphenhydramine hydrochloride is a first-generation histamine H1-receptor antagonist with anti-cholinergic effect. Diphenhydramine hydrochloride can across the ovine blood-brain barrier (BBB)[1][2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

297.85

Formula

C17H16D6ClNO
CAS 号

1189986-72-8
中文名称

盐酸苯海拉明 d6 (盐酸盐)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Simons FE. H1-receptor antagonists. Comparative tolerability and safety. Drug Saf. 1994;10(5):350-380.

    [3]. Sadiq MW, et al. Diphenhydramine active uptake at the blood-brain barrier and its interaction with oxycodone in vitro and in vivo. J Pharm Sci. 2011;100(9):3912-3923.

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