Aripiprazole (1,1,2,2,3,3,4,4-d8)(Synonyms: 阿立哌唑 d8)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物,专注于信号通路和疾病研究领域。
Aripiprazole (1,1,2,2,3,3,4,4-d8) (Synonyms: 阿立哌唑 d8)

Aripiprazole (1,1,2,2,3,3,4,4-d8) 是 Aripiprazole 的氘代物。Aripiprazole (OPC-14597) 是人5-HT1A受体部分激动剂,Ki 为4.2 nM。

Aripiprazole (1,1,2,2,3,3,4,4-d8)(Synonyms: 阿立哌唑 d8)

Aripiprazole (1,1,2,2,3,3,4,4-d8) Chemical Structure

CAS No. : 1089115-04-7

规格 是否有货
1 mg Check price and availability
10 mg Check price and availability

* Please select Quantity before adding items.

Aripiprazole (1,1,2,2,3,3,4,4-d8) 的其他形式现货产品:

Aripiprazole

生物活性

Aripiprazole (1,1,2,2,3,3,4,4-d8) is the deuterium labeled Aripiprazole. Aripiprazole (OPC-14597) is a human 5-HT1A receptor partial agonist with a Ki of 4.2 nM[1][2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

分子量

456.43

Formula

C23H19D8Cl2N3O2

CAS 号

1089115-04-7

中文名称

阿立哌唑 d8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Stip E, Tourjman V. et al. Aripiprazole in schizophrenia and schizoaffective disorder: A review. Clin Ther. 2010;32 Suppl 1:S3-20.

    [3]. Burris KD, Molski TF, Xu C et al. Aripiprazole, a novel antipsychotic, is a high-affinity partial agonist at human dopamine D2 receptors. J Pharmacol Exp Ther. 2002 Jul;302(1):381-9.

    [4]. Swainston Harrison T, Perry CM. Aripiprazole: a review of its use in schizophrenia and schizoaffective disorder. Drugs. 2004;64(15):1715-36.

    [5]. Nagasaka Y, Oda K, Iwatsubo T, Kawamura A, Usui T. Nagasaka Y, Oda K, Iwatsubo T, Kawamura A, Usui T. Effects of aripiprazole and its active metabolite dehydroaripiprazole on the activities of drug efflux transporters expressed both in the intestine and at the blood-brain barrier. Biopharm Drug Dispos. 2012 Jul 27. doi: 10.1002/bdd.1801.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务