Fenoterol-d6 hydrobromide(Synonyms: 非诺特罗氢溴酸盐 d6 (氢溴酸盐))

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Fenoterol-d6 hydrobromide (Synonyms: 非诺特罗氢溴酸盐 d6 (氢溴酸盐))

Fenoterol-d6 hydrobromide 是 Fenoterol hydrobromide 的氘代物。Fenoterol hydrobromide (Th-1165a) 是拟交感神经剂，是一种选择性的，具有口服活性 β2-肾上腺素受体 (β2-adrenoceptor) 激动剂。Fenoterol hydrobromide 是一种有效的支气管扩张剂，可用于与哮喘，支气管炎和其他阻塞性气道疾病相关的支气管痉挛的研究。

Fenoterol-d6 hydrobromide(Synonyms: 非诺特罗氢溴酸盐 d6 (氢溴酸盐))

Fenoterol-d6 hydrobromide Chemical Structure

CAS No. : 1286129-04-1

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生物活性

Fenoterol-d6 hydrobromide (Th-1165a-d6) is the deuterium labeled Fenoterol hydrobromide. Fenoterol hydrobromide (Th-1165a), a sympathomimetic agent, is a selective and orally active β2-adrenoceptor agonist. Fenoterol hydrobromide is an effective bronchodilator and can be used for bronchospasm associated with asthma, bronchitis and other obstructive airway diseases research[1][2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

390.30

Formula

C17H16D6BrNO4
CAS 号

1286129-04-1
中文名称

非诺特罗氢溴酸盐 d6 (氢溴酸盐)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. R C Heel, et al. Fenoterol: a review of its pharmacological properties and therapeutic efficacy in asthma. Drugs. 1978 Jan;15(1):3-32.

    [3]. Wei Wang, et al. Anti-inflammatory activities of fenoterol through β-arrestin-2 and inhibition of AMPK and NF-κB activation in AICAR-induced THP-1 cells. Biomed Pharmacother. 2016 Dec;84:185-190.

    [4]. Nada Choucair-Jaafar, et al. Beta2-adrenoceptor agonists alleviate neuropathic allodynia in mice after chronic treatment. Br J Pharmacol. 2009 Dec;158(7):1683-94.

    [5]. Amrita Datta, et al. High-throughput screening identified selective inhibitors of exosome biogenesis and secretion: A drug repurposing strategy for advanced cancer. Sci Rep. 2018 May 25;8(1):8161.

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