Valacyclovir-d8 hydrochloride(Synonyms: 盐酸伐昔洛韦 d8 (盐酸盐))

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Valacyclovir-d8 hydrochloride (Synonyms: 盐酸伐昔洛韦 d8 (盐酸盐))

Valacyclovir-d8 hydrochloride 是 Valacyclovir hydrochloride 的氘代物。Valacyclovir hydrochloride (Valaciclovir hydrochloride) 是一种口服有效的抗病毒药物，可以抑制单纯疱疹，带状疱疹和疱疹 B。Valacyclovir hydrochloride 抑制 HSV-1 W (50=2.9 μg/ml)。Valacyclovir hydrochloride 是 Aciclovir (HY-17422) 的前药。

Valacyclovir-d8 hydrochloride(Synonyms: 盐酸伐昔洛韦 d8 (盐酸盐))

Valacyclovir-d8 hydrochloride Chemical Structure

CAS No. : 1279033-32-7

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生物活性

Valacyclovir-d8 hydrochloride is the deuterium labeled Valacyclovir hydrochloride. Valacyclovir hydrochloride (Valaciclovir hydrochloride) is an orally active antiviral drug for herpes simplex, herpes zoster, and herpes B. Valacyclovir hydrochloride inhibits HSV-1 W (50=2.9 μg/ml). Valacyclovir hydrochloride is a prodrug of Aciclovir (HY-17422) [1][2][3][4][5].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

368.85

Formula

C13H13D8ClN6O4
CAS 号

1279033-32-7
中文名称

盐酸伐昔洛韦 d8 (盐酸盐)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Valacyclovir. New indication: for genital herpes, simpler administration. Can Fam Physician. 1999 Jul;45:1698-700, 1703-5.

    [3]. Lycke J, et al. Acyclovir levels in serum and cerebrospinal fluid after oral administration of valacyclovir. Antimicrob Agents Chemother. 2003 Aug;47(8):2438-41.

    [4]. Comparison of efficacies of famciclovir and valaciclovir against herpes simplex virus type 1 in a murineimmunosuppression model. Antimicrob Agents Chemother. 1995 May;39(5):1114-9.

    [5]. Dhaliwal DK, Romanowski EG, Yates KA, Valacyclovir inhibits recovery of ocular HSV-1 after experimental reactivation by excimer laser keratectomy. Cornea. 1999 Nov;18(6):693-9.

    [6]. Guo A, Hu P, Balimane PV, Interactions of a nonpeptidic drug, valacyclovir, with the human intestinal peptide transporter (hPEPT1) expressed in a mammalian cell line.J Pharmacol Exp Ther. 1999 Apr;289(1):448-54.

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