N-Desmethyl Galanthamine-d3(Synonyms: N-Norgalanthamine-d3)

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N-Desmethyl Galanthamine-d3 (Synonyms: N-Norgalanthamine-d3)

N-Desmethyl Galanthamine-d3 (N-Norgalanthamine-d3) 是 N-Desmethyl Galanthamine 的氘代物。N-Desmethyl Galanthamine 是的 Galanthamine 的代谢物。Galanthamine 是一种有效的乙酰胆碱酯酶 (AChE) 抑制剂，IC50 为 500 nM。

N-Desmethyl Galanthamine-d3(Synonyms: N-Norgalanthamine-d3)

N-Desmethyl Galanthamine-d3 Chemical Structure

CAS No. : 1128108-98-4

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生物活性

N-Desmethyl Galanthamine-d3 (N-Norgalanthamine-d3) is the deuterium labeled N-Desmethyl Galanthamine. N-Desmethyl Galanthamine is a metabolite of Galanthamine. Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC50 of 500 nM[1][2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

276.35

Formula

C16H16D3NO3
CAS 号

1128108-98-4
中文名称

N-去甲基加兰它敏氢溴酸盐 d3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Bachus R, et al. The O-demethylation of the antidementia drug galanthamine is catalysed by cytochrome P450 2D6. Pharmacogenetics. 1999;9(6):661-668.

    [3]. Melanie-Jayne R. Howes, et al. Acetylcholinesterase inhibitors of natural origin. International Journal of Research in Pharmaceutical and Biomedical Sciences 3(SI 1):67-86.

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