Risedronic Acid-d4(Synonyms: 利塞膦酸 d4)

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Risedronic Acid-d4 (Synonyms: 利塞膦酸 d4)

Risedronic Acid-d4 (Risedronate-d4) 是 Risedronic acid 的氘代物。Risedronic acid（Risedronate）能抑制破骨细胞介导的骨重吸收。

Risedronic Acid-d4 Chemical Structure

CAS No. : 1035438-80-2

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生物活性	Risedronic acid-d4 (Risedronate-d4) is the deuterium labeled Risedronic acid. Risedronic acid (Risedronate) is a pyridinyl biphosphonate which inhibits osteoclast-mediated bone resorption^[1]^[2].
体外研究 (In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	287.14
Formula	C₇H₇D₄NO₇P₂
CAS 号	1035438-80-2
中文名称	利塞膦酸 d4
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Giljevic Z, et al. Treatment of osteoporosis by risedronate– speed, efficacy and safety. Reumatizam. 2006;53(2):66-71. [3]. Jordao FM, et al. In vitro and in vivo antiplasmodial activities of risedronate and its interference with protein prenylation in Plasmodium falciparum. Antimicrob Agents Chemother. 2011 May;55(5):2026-31.

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