D-Mannitol-d8(Synonyms: Mannitol-d8; Mannite-d8)

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D-Mannitol-d8 (Synonyms: Mannitol-d8; Mannite-d8)

D-Mannitol-d8 (Mannitol-d8) 是 D-Mannitol 的氘代物。D-Mannitol是渗透性利尿剂，具有较弱的肾脏血管扩张活性。

D-Mannitol-d8(Synonyms: Mannitol-d8; Mannite-d8)

D-Mannitol-d8 Chemical Structure

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生物活性

D-Mannitol-d8 (Mannitol-d8) is the deuterium labeled D-Mannitol. D-Mannitol is an osmotic diuretic agent and a weak renal vasodilator.

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

190.22

Formula

C6H6D8O6
中文名称

D-甘露醇 d8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Tan, K., et al., The mannitol operon repressor MtlR belongs to a new class of transcription regulators in bacteria. J Biol Chem, 2009. 284(52): p. 36670-9.

    [3]. Nishiyama, A., et al., Mannitol lowers fat digestibility and body fat accumulation in both normal and cecectomized rats. J Nutr Sci Vitaminol (Tokyo), 2009. 55(3): p. 242-51.

    [4]. Hanieh, H. and E. Sakaguchi, Effect of D-mannitol on feed digestion and cecotrophic system in rabbits. Anim Sci J, 2009. 80(2): p. 157-62.

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