Docosahexaenoic acid-d5 methyl ester(Synonyms: Methyl docosahexaenoate-d5; all cis-DHA methyl ester-d5)

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Docosahexaenoic acid-d5 methyl ester (Synonyms: Methyl docosahexaenoate-d5; all cis-DHA methyl ester-d5)

Docosahexaenoic acid-d5 methyl ester (Methyl docosahexaenoate-d5) 是 Docosahexaenoic Acid methyl ester 的氘代物。Docosahexaenoic Acid methyl ester 是一种甲基化的二十二碳六烯酸类似物，可以插入膜磷脂中而不被氧化或水解。

Docosahexaenoic acid-d5 methyl ester(Synonyms: Methyl docosahexaenoate-d5; all cis-DHA methyl ester-d5)

Docosahexaenoic acid-d5 methyl ester Chemical Structure

CAS No. : 2687960-96-7

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生物活性

Docosahexaenoic acid-d5 methyl ester (Methyl docosahexaenoate-d5) is the deuterium labeled Docosahexaenoic Acid methyl ester. Docosahexaenoic Acid methyl ester is a methylated docosahexaenoic acid analog which can be intercalated into membrane phospholipids without being oxidized or hydrolyzed[1][2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

347.55

Formula

C23H29D5O2
CAS 号

2687960-96-7
中文名称

二十二六烯酸甲酯 d5 甲酯
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Taha AY, et al. Selective reduction of excitatory hippocampal sharp waves by docosahexaenoic acid and its methyl ester analog ex-vivo. Brain Res. 2013 Nov 6;1537:9-17.

    [3]. Liu W, et al. Formation of high-molecular-weight protein adducts by methyl docosahexaenoate peroxidation products. Biochim Biophys Acta. 2007 Feb;1774(2):258-66.

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