Antipyrine-d3(Synonyms: Phenazone-d3; Phenazon-d3)

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Antipyrine-d3 (Synonyms: Phenazone-d3; Phenazon-d3)

Antipyrine-d3 (Phenazone-d3) 是 Antipyrine 的氘代物。Antipyrine (Phenazone) 是一种退烧剂和止痛剂。Antipyrine 可被用作氧化药物代谢的探针药物。Antipyrine 已被广泛用于评估人类的肝氧化能力。

Antipyrine-d3 Chemical Structure

CAS No. : 65566-62-3

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生物活性	Antipyrine-d3 (Phenazone-d3) is the deuterium labeled Antipyrine. Antipyrine (Phenazone) is an antipyretic and analgesic. Antipyrine can be used as a probe drug for oxidative drug metabolism. Antipyrine has been widely used in assessment of hepatic oxidative capacity^[1]^[2].
体外研究 (In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	191.24
Formula	C₁₁H₉D₃N₂O
CAS 号	65566-62-3
中文名称	安替比林 d3
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Stevenson, I.H., Factors influencing antipyrine elimination. Br J Clin Pharmacol, 1977. 4(3): p. 261-5. [3]. Engel G, et, al. Antipyrine as a probe for human oxidative drug metabolism: identification of the cytochrome P450 enzymes catalyzing 4-hydroxyantipyrine, 3-hydroxymethylantipyrine, and norantipyrine formation. Clin Pharmacol Ther. 1996 Jun;59(6):613-23.

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