DL-Phenylalanine-d5 hydrochloride(Synonyms: 2-Amino-3-phenylpropionic acid-d5 hydrochloride)

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DL-Phenylalanine-d5 hydrochloride (Synonyms: 2-Amino-3-phenylpropionic acid-d5 hydrochloride)

DL-Phenylalanine-d5 (2-Amino-3-phenylpropionic acid-d5) hydrochloride 是 DL-Phenylalanine 的氘代物。L-Phenylalanine hydrochloride 是分离自大肠杆菌的必需氨基酸。L-Phenylalanine hydrochloride 是一种电压依赖性 α2δ 亚基 Ca2+ 通道拮抗剂，Ki 为 980 nM。L-Phenylala

DL-Phenylalanine-d5 hydrochloride(Synonyms: 2-Amino-3-phenylpropionic acid-d5 hydrochloride)

DL-Phenylalanine-d5 hydrochloride Chemical Structure

规格 价格 是否有货
5 mg ￥1300 询问价格 & 货期
10 mg ￥2000 询问价格 & 货期
25 mg ￥4200 询问价格 & 货期
50 mg ￥6700 询问价格 & 货期
100 mg ￥10800 询问价格 & 货期

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生物活性

DL-Phenylalanine-d5 (2-Amino-3-phenylpropionic acid-d5) hydrochloride is the deuterium labeled DL-Phenylalanine hydrochloride. L-Phenylalanine hydrochloride is an essential amino acid isolated from Escherichia coli. L-Phenylalanine hydrochloride is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine hydrochloride is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine hydrochloride is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

206.68

Formula

C9H7D5ClNO2
中文名称

L-苯丙氨酸 d5 (盐酸盐)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Wu WB, et al. Enhancement of l-phenylalanine production in Escherichia coli by heterologous expression of Vitreoscilla hemoglobin. Biotechnol Appl Biochem. 2018 May;65(3):476-483.

    [3]. Mortell KH, et al. Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1138-41.

    [4]. Glushakov AV, et al. Specific inhibition of N-methyl-D-aspartate receptor function in rat hippocampal neurons by L-phenylalanine at concentrations observed during phenylketonuria. Mol Psychiatry. 2002;7(4):359-67.

    [5]. Glushakov AV, et al. L-phenylalanine selectively depresses currents at glutamatergic excitatory synapses. J Neurosci Res. 2003 Apr 1;72(1):116-24.

    [6]. Glushakov AV, et al. Long-term changes in glutamatergic synaptic transmission in phenylketonuria. Brain. 2005 Feb;128(Pt 2):300-7.

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