Pyridoxal phosphate-d5(Synonyms: 磷酸吡哆醛 d5)

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Pyridoxal phosphate-d5 (Synonyms: 磷酸吡哆醛 d5)

Pyridoxal phosphate-d5 (Pyridoxal 5′-phosphate-d5) 是 Pyridoxal phosphate 的氘代物。Pyridoxal phosphate 是维生素 B6 的活性形式，可以抑制 reverse transcriptases 的活性，用于迟发性运动障碍症的研究。

Pyridoxal phosphate-d5 Chemical Structure

CAS No. : 1246818-16-5

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生物活性	Pyridoxal phosphate-d5 (Pyridoxal 5′-phosphate-d5) is the deuterium labeled Pyridoxal phosphate. Pyridoxal phosphate is the active form of vitamin B6, acts as an inhibitor of reverse transcriptases, and is used for the treatment of tardive dyskinesia^[1]^[2].
体外研究 (In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	252.17
Formula	C₈H₅D₅NO₆P
CAS 号	1246818-16-5
中文名称	磷酸吡哆醛 d5
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Modak MJ. Pyridoxal 5′ phosphate: a selective inhibitor of oncornaviral DNA polymerases. Biochem Biophys Res Commun. 1976 Jul 12;71(1):180-7. [3]. Grin IR, et al. Inactivation of NEIL2 DNA glycosylase by pyridoxal phosphate reveals a loop important for substrate binding. Biochem Biophys Res Commun. 2010 Mar 26;394(1):100-5.

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