Tolbutamide-13C(Synonyms: 甲苯磺丁脲 13C)

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Tolbutamide-13C (Synonyms: 甲苯磺丁脲 13C)

Tolbutamide-13C 是一种 13C 标记的 Tolbutamide。Tolbutamide是第一代钾离子通道阻断剂,是磺酰脲类口服活性的降糖化合物。

Tolbutamide-13C(Synonyms: 甲苯磺丁脲 13C)

Tolbutamide-13C Chemical Structure

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生物活性

Tolbutamide-13C is the 13C-labeled Tolbutamide. Tolbutamide is a first generation potassium channel blocker, sulfonylurea oral hypoglycemic drug.

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

269.32

Formula

C1113CH16N2O3S

中文名称

甲苯磺丁脲 13C

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Wray, H.L. and A.W. Harris, Adenosine 3′, 5′-monophosphate-dependent protein kinase in adipose tissue: inhibition by tolbutamide. Biochem Biophys Res Commun, 1973. 53(1): p. 291-4.

    [3]. Sanchez-Alvarez, R., et al., Tolbutamide reduces glioma cell proliferation by increasing connexin43, which promotes the up-regulation of p21 and p27 and subsequent changes in retinoblastoma phosphorylation. Glia, 2006. 54(2): p. 125-34.

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