Urapidil-d4 hydrochloride(Synonyms: 盐酸乌拉地尔 d4 (盐酸盐))

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Urapidil-d4 hydrochloride (Synonyms: 盐酸乌拉地尔 d4 (盐酸盐))

Urapidil-d4 hydrochloride 是 Urapidil hydrochloride 的氘代物。Urapidil盐酸盐是α1-肾上腺素受体拮抗剂和5-HT1A受体激动剂。

Urapidil-d4 hydrochloride Chemical Structure

CAS No. : 1794979-63-7

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生物活性	Urapidil-d4 hydrochloride is the deuterium labeled Urapidil hydrochloride. Urapidil hydrochloride is an α1-adrenoceptor antagonist and 5-HT_1A receptor agonist^[1]^[2].
体外研究 (In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	427.96
Formula	C₂₀H₂₆D₄ClN₅O₃
CAS 号	1794979-63-7
中文名称	盐酸乌拉地尔 d4 (盐酸盐)
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Gross, G., G. Hanft, and N. Kolassa, Urapidil and some analogues with hypotensive properties show high affinities for 5-hydroxytryptamine (5-HT) binding sites of the 5-HT1A subtype and for alpha 1-adrenoceptor binding sites. Naunyn Schmiedebergs Arch Pharmacol, 1987. 336(6): p. 597-601. [3]. Buch, J., Urapidil, a dual-acting antihypertensive agent: Current usage considerations. Adv Ther, 2010. 27(7): p. 426-43.

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