Docosahexaenoic acid-d5(Synonyms: DHA-d5; Cervonic acid-d5)

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Docosahexaenoic acid-d5 (Synonyms: DHA-d5; Cervonic acid-d5)

Docosahexaenoic acid-d5 (DHA-d5) 是 Docosahexaenoic Acid 的氘代物。Docosahexaenoic Acid (DHA)是丰富地存在于脑和视网膜中的ω-3脂肪酸，可以直接从鱼油和母乳中获得。

Docosahexaenoic acid-d5(Synonyms: DHA-d5; Cervonic acid-d5)

Docosahexaenoic acid-d5 Chemical Structure

CAS No. : 1197205-71-2

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生物活性

Docosahexaenoic acid-d5 (DHA-d5) is the deuterium labeled Docosahexaenoic Acid. Docosahexaenoic Acid (DHA) is an omega-3 fatty acid abundantly present brain and retina. It can be obtained directly from fish oil and maternal milk.

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

333.52

Formula

C22H27D5O2
CAS 号

1197205-71-2
中文名称

二十二碳六烯酸 d5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Horrocks LA, et al. Health benefits of docosahexaenoic acid (DHA). Pharmacol Res. 1999 Sep;40(3):211-25.

    [3]. Gharami K, et al. Essential role of docosahexaenoic acid towards development of a smarter brain. Neurochem Int. 2015 Oct;89:51-62.

    [4]. Lengqvist J, et al. Polyunsaturated fatty acids including docosahexaenoic and arachidonic acid bind to the retinoid Xreceptor alpha ligand-binding domain. Mol Cell Proteomics. 2004 Jul;3(7):692-703.

    [5]. Gamoh S, et al. Chronic administration of docosahexaenoic acid improves reference memory-related learning ability in young rats. Neuroscience. 1999;93(1):237-41.

    [6]. Ozsoy O, et al. The influence and the mechanism of docosahexaenoic acid on a mouse model of Parkinson’s disease. Neurochem Int. 2011 Oct;59(5):664-70.

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