Butylphthalide-d3(Synonyms: 3-n-Butylphthalide-d3; 3-Butylphthalide-d3)

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Butylphthalide-d3 (Synonyms: 3-n-Butylphthalide-d3; 3-Butylphthalide-d3)

Butylphthalide-d3 (3-n-Butylphthalide-d3) 是 Butylphthalide 的氘代物。Butylphthalide(3-n-Butylphthalide)是抗脑缺血药物，最初从芹菜种中分离出，对中风动物模型显示有效。

Butylphthalide-d3(Synonyms: 3-n-Butylphthalide-d3; 3-Butylphthalide-d3)

Butylphthalide-d3 Chemical Structure

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生物活性

Butylphthalide-d3 (3-n-Butylphthalide-d3) is the deuterium labeled Butylphthalide. Butylphthalide(3-n-Butylphthalide), an anti-cerebral-ischemia drug, is first isolated from the seeds of celery and showes efficacy in animal models of stroke.

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

193.26

Formula

C12H11D3O2
中文名称

丁基苯酞 d3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Cui LY, et al. Ninety-day administration of dl-3-n-butylphthalide for acute ischemic stroke: a randomized, double-blind trial. Chin Med J (Engl). 2013;126(18):3405-10.

    [3]. Zhao W, et al. 3-N-butylphthalide improves neuronal morphology after chronic cerebral ischemia. Neural Regen Res. 2014 Apr 1;9(7):719-26.

    [4]. Wang X, et al. Design, synthesis and biological evaluation of hydrogen sulfide releasing derivatives of 3-n-butylphthalide as potential antiplatelet and antithrombotic agents. Org Biomol Chem. 2014 Aug 21;12(31):5995-6004.

    [5]. Wang F, et al. Improvement of cognitive deficits in SAMP8 mice by 3-n-butylphthalide. Neurol Res. 2014 Mar;36(3):224-33.

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