Sulfadoxine-d4(Synonyms: Sulphadoxine-d4)

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Sulfadoxine-d4 (Synonyms: Sulphadoxine-d4)

Sulfadoxine-d4 (Sulphadoxine-d4) 是 Sulfadoxine 的氘代物。Sulfadoxine(Sulphadoxine)是长效的磺胺类化合物，常与pyrimethamine结合起到抗疟疾作用。Sulfadoxine 抑制 HIV 在外周血单核细胞中的复制。

Sulfadoxine-d4 Chemical Structure

CAS No. : 1330266-05-1

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生物活性	Sulfadoxine-d4 (Sulphadoxine-d4) is the deuterium labeled Sulfadoxine. Sulfadoxine(Sulphadoxine) is a long acting sulfonamide that is used, usually in combination with other drugs, for respiratory, urinary tract and malarial infections. Sulfadoxine inhibits HIV replication in peripheral blood mononuclear cells.
体外研究 (In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	314.35
Formula	C₁₂H₁₀D₄N₄O₄S
CAS 号	1330266-05-1
中文名称	磺胺多辛 d4
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. http://www.malaria-ipca.com/sulphadoxine_pyrimethamine.html [3]. http://en.wikipedia.org/wiki/Sulfadoxine/pyrimethamine [4]. D’Alessandro S, et al. The Use of Antimalarial Drugs against Viral Infection. Microorganisms. 2020 Jan 8;8(1). pii: E85.

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