Ipragliflozin-d5(Synonyms: ASP1941-d5)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Ipragliflozin-d5 (Synonyms: ASP1941-d5)

Ipragliflozin-d5 (ASP1941-d5) 是 Ipragliflozin 的氘代物。Ipragliflozin (ASP1941) 是一种有效的，具有口服活性的选择性 SGLT2 抑制剂，对人 SGLT2 和 SGLT1，大鼠 SGLT2 和 SGLT1，小鼠 SGLT2 和 SGLT1 的 IC₅₀ 分别为 7.38 和 1876 nM，6.73 和 1166 nM，5.64 和 1380 nM。具有抗糖尿病活性^[1]

Ipragliflozin-d5 Chemical Structure

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

* Please select Quantity before adding items.

生物活性	Ipragliflozin-d5 (ASP1941-d5) is the deuterium labeled Ipragliflozin. Ipragliflozin (ASP1941) is an orally active and selective SGLT2 inhibitor with IC₅₀s of 7.38 and 1876 nM, 6.73 and 1166 nM, 5.64 and 1380 nM for human SGLT2 and SGLT1, rat SGLT2 and SGLT1, mouse SGLT2 and SGLT1, respectively. Antidiabetic agent^[1].
体外研究 (In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	409.48
Formula	C₂₁H₁₆D₅FO₅S
中文名称	伊格列净 d5
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Atsuo Tahara, et al. Pharmacological profile of ipragliflozin (ASP1941), a novel selective SGLT2 inhibitor, in vitro and in vivo. Naunyn Schmiedebergs Arch Pharmacol. 2012 Apr;385(4):423-36. [3]. Shiho Komatsu, et al. SGLT2 inhibitor ipragliflozin attenuates breast cancer cell proliferation. Endocr J. 2020 Jan 28;67(1):99-106.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务