(S)-(+)-Ibuprofen D3(Synonyms: (S)-Ibuprofen D3)

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(S)-(+)-Ibuprofen D3 (Synonyms: (S)-Ibuprofen D3)

(S)-(+)-Ibuprofen D3 ((S)-Ibuprofen D3) 是(S)-(+)-Ibuprofen 的氘代物。(S)-(+)-Ibuprofen 是 Ibuprofen 的 S 型异构体，可抑制 COX-1 和 COX-2 活性，IC50 为 2.1 μM 和 1.6 μM。(S)-(+)-Ibuprofen 具有止痛，抗炎和解热作用。

(S)-(+)-Ibuprofen D3(Synonyms: (S)-Ibuprofen D3)

(S)-(+)-Ibuprofen D3 Chemical Structure

CAS No. : 1329643-44-8

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生物活性

(S)-(+)-Ibuprofen D3 ((S)-Ibuprofen D3) is a deuterium labeled (S)-(+)-Ibuprofen. (S)-(+)-Ibuprofen is the S(+)-enantiomer of Ibuprofen that inhibits COX-1 and COX-2 activity with IC50s of 2.1 μM and 1.6 μM. (S)-(+)-Ibuprofen has analgesic, antiinflammatory and antipyretic effects[1][2].

IC50 & Target

COX-1

2.1 μM (IC50)

COX-2

1.6 μM (IC50)

分子量

209.30

Formula

C13H15D3O2
CAS 号

1329643-44-8
中文名称

(S)-(+)-布洛芬 D3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Evans AM, et al. Comparative pharmacology of S(+)-ibuprofen and (RS)-ibuprofen. Clin Rheumatol. 2001 Nov;20 Suppl 1:S9-14.

    [2]. Xu HR, et al. The effect of CYP2C19 activity on pharmacokinetics of lansoprazole and its active metabolites in healthy subjects. Pharm Biol. 2010 Aug;48(8):947-52.

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