Climbazole-d4(Synonyms: BAY-e 6975-d4)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Climbazole-d4 (Synonyms: BAY-e 6975-d4)

Climbazole-d4 (BAY-e 6975-d4) 是 Climbazole 的氘代物。Climbazole (BAY-e 6975) 是一种有效的抗真菌剂 (antifungal)。具有抗头皮屑效果。Climbazole 还是大鼠肝细胞色素 P450 的强诱导剂。

Climbazole-d4 Chemical Structure

CAS No. : 1185117-79-6

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生物活性	Climbazole-d4 (BAY-e 6975-d4) is the deuterium labeled Climbazole. Climbazole (BAY-e 6975) is a potent antifungal agent. Climbazole also is a potent inducer of rat hepatic cytochrome P450^[2].
体外研究 (In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	296.79
Formula	C₁₅H₁₃D₄ClN₂O₂
CAS 号	1185117-79-6
中文名称	氯咪巴唑 d4
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Amrita Datta, et al. High-throughput screening identified selective inhibitors of exosome biogenesis and secretion: A drug repurposing strategy for advanced cancer. Sci Rep. 2018 May 25;8(1):8161. [3]. Y Kobayashi, et al. Climbazole is a new potent inducer of rat hepatic cytochrome P450. J Toxicol Sci. 2001 Aug;26(3):141-50.

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