Memantine-d6 hydrochloride(Synonyms: 盐酸美金刚 d6 (盐酸盐))

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Memantine-d6 hydrochloride (Synonyms: 盐酸美金刚 d6 (盐酸盐))

Memantine-d6 hydrochloride 是 Memantine hydrochloride 的氘代物。Memantine (D-145) hydrochloride 是金刚胺衍生物，是一种温和的 NMDA 受体 (NMDA receptor) 非竞争性拮抗剂, 能够抑制 CYP2B6 和 CYP2D6。

Memantine-d6 hydrochloride(Synonyms: 盐酸美金刚 d6 (盐酸盐))

Memantine-d6 hydrochloride Chemical Structure

CAS No. : 1189713-18-5

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生物活性

Memantine-d6 hydrochloride is the deuterium labeled Memantine hydrochloride. Memantine (hydrochloride) (D-145 (hydrochloride)) is a moderate affinity, uncompetitive NMDA receptor antagonist, inhibit CYP2B6 and CYP2D6 with Ki of 0.51 nM and 94.9 μM, respectively[1].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

221.80

Formula

C12H16D6ClN
CAS 号

1189713-18-5
中文名称

盐酸美金刚 d6 (盐酸盐)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Robinson, D.M. and G.M. Keating, Memantine: a review of its use in Alzheimer’s disease. Drugs, 2006. 66(11): p. 1515-34.

    [3]. Chen, H.S., et al., Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity. J Neurosci, 1992. 12(11): p. 4427-36.

    [4]. Chen, H.S. and S.A. Lipton, Mechanism of memantine block of NMDA-activated channels in rat retinal ganglion cells: uncompetitive antagonism. J Physiol, 1997. 499 ( Pt 1): p. 27-46.

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