Mianserin-d3 hydrochloride(Synonyms: Org GB 94-d3)

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Mianserin-d3 hydrochloride (Synonyms: Org GB 94-d3)

Mianserin-d3 hydrochloride (Org GB 94-d3) 是 Mianserin hydrochloride 的氘代物。Mianserin hydrochloride (Org GB 94) 是 H1 受体反向激动剂，有抗抑郁活性。

Mianserin-d3 hydrochloride Chemical Structure

CAS No. : 1219804-97-3

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生物活性	Mianserin-d3 hydrochloride (Org GB 94-d3) is the deuterium labeled Mianserin hydrochloride. Mianserin hydrochloride (Org GB 94) is a H1 receptor inverse agonist and is a psychoactive agent of the tetracyclic antidepressant.
体外研究 (In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	303.84
Formula	C₁₈H₁₈D₃ClN₂
CAS 号	1219804-97-3
中文名称	盐酸米安色林 d3 (盐酸盐)
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Olianas MC,et al. The atypical antidepressant mianserin exhibits agonist activity at κ-opioid receptors. Br J Pharmacol. 2012 Nov;167(6):1329-41. [3]. Roeder T. High-affinity antagonists of the locust neuronal octopamine receptor. Eur J Pharmacol. 1990 Nov 27;191(2):221-4.

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