(S)-Flurbiprofen-d3(Synonyms: Esflurbiprofen-d3)

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(S)-Flurbiprofen-d3 (Synonyms: Esflurbiprofen-d3)

(S)-Flurbiprofen-d3 (Esflurbiprofen-d3) 是 (S)-Flurbiprofen 的氘代物。(S)-Flurbiprofen 是 Flurbiprofen的活性对映体，其对COX-1 和COX-2 的IC50 分别为0.48 μM 和 0.47 μM。

(S)-Flurbiprofen-d3(Synonyms: Esflurbiprofen-d3)

(S)-Flurbiprofen-d3 Chemical Structure

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生物活性

(S)-Flurbiprofen-d3 (Esflurbiprofen-d3) is the deuterium labeled (S)-Flurbiprofen. (S)-Flurbiprofen is an active enantiomer of Flurbiprofen, with IC50 values of 0.48 μM and 0.47 μM for COX-1 and COX-2, respectively[1].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

247.28

Formula

C15H10D3FO2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. A Carabaza, et al. Stereoselective Inhibition of Inducible Cyclooxygenase by Chiral Nonsteroidal Antiinflammatory Drugs. J Clin Pharmacol. 1996 Jun;36(6):505-12.

    [3]. B Averbeck, et al. Inflammatory Mediators Do Not Stimulate CGRP Release if Prostaglandin Synthesis Is Blocked by S(+)-flurbiprofen in Isolated Rat Skin. Inflamm Res. 2003 Dec;52(12):519-23.

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