(R)-Praziquantel-d11(Synonyms: (R)-吡喹酮 D11)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物,专注于信号通路和疾病研究领域。
(R)-Praziquantel-d11 (Synonyms: (R)-吡喹酮 D11)

(R)-Praziquantel D11 是 (R)-Praziquantel 的氘代物。(R)-Praziquantel 是 Praziquantel 的活性对映体,是一种人 5-HT2B 受体的部分激动剂。(R)-Praziquantel 用作驱虫药,抗血吸虫。

(R)-Praziquantel-d11(Synonyms: (R)-吡喹酮 D11)

(R)-Praziquantel-d11 Chemical Structure

CAS No. : 1399880-38-6

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生物活性

(R)-Praziquantel D11 is the deuterium labeled (R)-Praziquantel. (R)-Praziquantel, the active enantiomer of Praziquantel, is a partial agonist of the human 5-HT2B receptor. (R)-Praziquantel acts as an antischistosomal eutomer[1].

IC50 & Target[1]

5-HT2B Receptor

 

Antischistosomal

 

体外研究
(In Vitro)

(R)-Praziquantel ((R)-PZQ) is a G-protein-coupled receptor ligand. (R)-Praziquantel modulation of serotoninergic signaling occurs over a concentration range sufficient to regulate vascular tone of the mesenteric blood vessels where the adult parasites reside within their host. The important anthelmintic is supported by a broad, cross species polypharmacology with (R)-Praziquantel modulating signaling events in both host and parasite[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

323.47

Formula

C19H13D11N2O2

CAS 号

1399880-38-6

中文名称

(R)-吡喹酮 D11

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Chan JD, et al. The anthelmintic praziquantel is a human serotoninergic G-protein-coupled receptor ligand. Nat Commun. 2017 Dec 5;8(1):1910.

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