Flavoxate-d4 hydrochloride(Synonyms: 盐酸黄酮哌酯 d4 (盐酸盐))

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Flavoxate-d4 hydrochloride (Synonyms: 盐酸黄酮哌酯 d4 (盐酸盐))

Flavoxate-d4 hydrochloride 是 Flavoxate hydrochloride 的氘代物。Flavoxate(DW-61)盐酸盐是毒蕈碱受体AChR拮抗剂， IC50为12.2 μM。

Flavoxate-d4 hydrochloride(Synonyms: 盐酸黄酮哌酯 d4 (盐酸盐))

Flavoxate-d4 hydrochloride Chemical Structure

CAS No. : 1189678-43-0

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生物活性

Flavoxate-d4 hydrochloride (Rec-7-0040-d4) is the deuterium labeled Flavoxate hydrochloride. Flavoxate Hydrochloride is a muscarinic AChR antagonist used in various urinary syndromes and as an antispasmodic[1][2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

431.95

Formula

C24H22D4ClNO4
CAS 号

1189678-43-0
中文名称

盐酸黄酮哌酯 d4 (盐酸盐)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Dansette, P.M., M. Jaoen, and C. Pons, HMG-CoA reductase activity in human liver microsomes: comparative inhibition by statins. Exp Toxicol Pathol, 2000. 52(2): p. 145-8.

    [3]. Kimura, Y., et al., Mechanisms of the suppression of the bladder activity by flavoxate. Int J Urol, 1996. 3(3): p. 218-27.

    [4]. Oka, M., et al., Brain pertussis toxin-sensitive G proteins are involved in the flavoxate hydrochloride-induced suppression of the micturition reflex in rats. Brain Res, 1996. 727(1-2): p. 91-8.

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