Triclocarban-d4(Synonyms: 3,4,4′-Trichlorocarbanilide-d4)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Triclocarban-d4 (Synonyms: 3,4,4′-Trichlorocarbanilide-d4)

Triclocarban-d4 (3,4,4′-Trichlorocarbanilide-d4) 是 Triclocarban 的氘代物。Triclocarban (3,4,4′-Trichlorocarbanilide) 是一种广谱抗菌化合物，广泛应用于肥皂、护肤霜、牙膏和除臭剂的生产。Triclocarban 是一种潜在的内分泌干扰化学物质，具有调节雄激素和雌激素活性以及其他激素介导的生物过程的能力。

Triclocarban-d4 Chemical Structure

CAS No. : 1219799-29-7

规格		是否有货
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生物活性	Triclocarban-d4 (3,4,4′-Trichlorocarbanilide-d4) is the deuterium labeled Triclocarban. Triclocarban (3,4,4′-Trichlorocarbanilide), a broad spectrum antibacterial compound, is widely used in a broad range of applications such as the production of soaps, skin creams, toothpastes and deodorants. Triclocarban is a potential endocrine-disrupting chemical with the capacity to modulate androgen and estrogen activities as well as other hormone-mediated biological processes^[1]^[2]^[3].
体外研究 (In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	319.61
Formula	C₁₃H₅D₄Cl₃N₂O
CAS 号	1219799-29-7
中文名称	三氯卡班 d4
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Kanbara Y, et al. Nanomolar concentration of triclocarban increases the vulnerability of rat thymocytes to oxidative stress. J Toxicol Sci. 2013 Feb;38(1):49-55. [3]. Huang H, et al. The in vitro estrogenic activities of triclosan and triclocarban. J Appl Toxicol. 2014 Sep;34(9):1060-7. [4]. Kennedy RC, et al. Early life triclocarban exposure during lactation affects neonate rat survival. Reprod Sci. 2015 Jan;22(1):75-89.

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