Entecavir-d2(Synonyms: BMS200475-d2; SQ34676-d2)

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Entecavir-d2 (Synonyms: BMS200475-d2; SQ34676-d2)

Entecavir-d2 (BMS200475-d2) 是 Entecavir 的氘代物。Entecavir（SQ 34676; BMS 200475）是有选择且有效地HBV抑制剂，在HepG2细胞中的EC50值为3.75 nM。

Entecavir-d2(Synonyms: BMS200475-d2; SQ34676-d2)

Entecavir-d2 Chemical Structure

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生物活性

Entecavir-d2 (BMS200475-d2) is the deuterium labeled Entecavir. Entecavir (SQ 34676; BMS 200475) is a potent and selective inhibitor of HBV, with an EC50 of 3.75 nM in HepG2 cell.

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

279.29

Formula

C12H13D2N5O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Innaimo SF, et al. Identification of?BMS-200475?as a potent and selective inhibitor of hepatitis B virus. Antimicrob Agents Chemother. 1997 Jul;41(7):1444-9.

    [3]. Rivkin A, et al. A review of entecavir in the treatment of chronic hepatitis B infection. Curr Med Res Opin.?2005 Nov;21(11):1845-57.

    [4]. Genovesi EV, et al. Efficacy of the carbocyclic 2′-deoxyguanosine nucleoside?BMS-200475?in the woodchuck model of hepatitis B virus infection. Antimicrob Agents Chemother.?1998 Dec;42(12):3209-18.

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