Adefovir-d4 diphosphate triethylamine(Synonyms: 阿德福韦 d4 二磷酸 (三乙胺盐))

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Adefovir-d4 diphosphate triethylamine (Synonyms: 阿德福韦 d4 二磷酸 (三乙胺盐))

Adefovir-d4 diphosphate triethylamine 是 Adefovir 的氘代物。Adefovir (GS-0393) 是一种单磷酸腺苷类似物抗病毒剂，在细胞内转化为 Adefovir diphosphate 后可抑制 HBV DNA 聚合酶。Adefovir 在 HepG2.2.15 细胞系中对 HBV 的 IC50 为 0.7 μM。Adefovir 对多种病毒(包括 HBV 和疱疹病毒)具有良好的抗病毒活性。

Adefovir-d4 diphosphate triethylamine(Synonyms: 阿德福韦 d4 二磷酸 (三乙胺盐))

Adefovir-d4 diphosphate triethylamine Chemical Structure

CAS No. : 1346604-40-7

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生物活性

Adefovir-d4 diphosphate triethylamine is the deuterium labeled Adefovir. Adefovir (GS-0393) is an adenosine monophosphate analog antiviral agent that after intracellular conversion to Adefovir diphosphate inhibits HBV DNA polymerase. Adefovir has an IC50 of 0.7 μM against HBV in the HepG2.2.15 cell line. Adefovir has good antiviral activity against several viruses, including HBV and herpesviruses[1][2][3].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

538.36

Formula

C14H25D4N6O10P3
CAS 号

1346604-40-7
中文名称

阿德福韦 d4 二磷酸 (三乙胺盐)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. X.-X.Zhou, et al. 7.11 – Deoxyribonucleic Acid Viruses: Antivirals for Herpesviruses and Hepatitis B Virus. Comprehensive Medicinal Chemistry II. Volume 7, 2007, Pages 295-327.

    [3]. Marcellin P, et al. Adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B. N Engl J Med. 2003 Feb 27;348(9):808-16.

    [4]. Leah A.Burke, et al. 155 – Drugs to Treat Viral Hepatitis. Infectious Diseases. Volume 2, 2017, Pages 1327-1332.

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