Tizoxanide-d4 glucuronide

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Tizoxanide-d4 glucuronide 

Tizoxanide glucuronide-D4 是氘标记的 Tizoxanide glucuronide。Tizoxanide glucuronide 是硝唑奈德 (HY-B0217) 的代谢物 (metabolite)，具有细胞穿透性，可抑制寄生虫 (parasite) C. parvum 的无性和有性发育阶段。

Tizoxanide-d4 glucuronide

Tizoxanide-d4 glucuronide Chemical Structure

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生物活性

Tizoxanide glucuronide-D4 is the deuterium labeled Tizoxanide glucuronide. Tizoxanide glucuronide is the metabolite of Nitazoxanide (HY-B0217) and is cell-permeable to inhibit asexual and sexual stages development of parasite C. parvum[1].

IC50 & Target

IC50: parasite[1]
体外研究
(In Vitro)

Tizoxanide glucuronide (1-50 μg/ml; 46 hours) has effects on parasite development of Cryptosporidium parvum in HCT-8 cells. It exhibits MIC50 values of 2.2 μg/ml; 45.2 μg/ml; 11.7 μg/ml and 2.8 μg/ml in a sexual and sexual stages, sporozoite stage, asexual stages and sexual stages, respectively[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

445.39

Formula

C16H11D4N3O10S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. G Gargala , et al. Efficacy of Nitazoxanide, Tizoxanide and Tizoxanide Glucuronide Against Cryptosporidium Parvum Development in Sporozoite-Infected HCT-8 Enterocytic Cells. J Antimicrob Chemother. 2000 Jul;46(1):57-60.

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