Tasimelteon-d5(Synonyms: BMS-214778-d5; VEC-162-d5)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Tasimelteon-d5 (Synonyms: BMS-214778-d5; VEC-162-d5)

Tasimelteon-d5 (BMS-214778-d5) 是 Tasimelteon 的氘代物。Tasimelteon (BMS-214778) 是一种具有口服活性，选择性的双重褪黑激素受体激动剂 (DMRA)。Tasimelteon 对 MT2 受体的亲和力是 MT1 受体的 2.1-4.4 倍。Tasimelteon 是一种昼夜节律性调节剂，具有用于非 24 小时睡眠/觉醒障碍 (Non-24) 的潜力。

Tasimelteon-d5 Chemical Structure

CAS No. : 1962124-51-1

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

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生物活性	Tasimelteon-d5 (BMS-214778-d5) is the deuterium labeled Tasimelteon. Tasimelteon (BMS-214778) is an orally active and selective dual melatonin receptor agonist (DMRA). Tasimelteon has 2.1-4.4 times greater affinity for the MT2 receptor than for the MT1 receptor. Tasimelteon is a circadian regulator and has the potential for Non-24-Hour Sleep-Wake Disorder (Non-24)^[1]^[2].
体外研究 (In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	250.35
Formula	C₁₅H₁₄D₅NO₂
CAS 号	1962124-51-1
中文名称	他司美琼 d5
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Christian Lavedan, et al. Tasimelteon: a selective and unique receptor binding profile. Neuropharmacology. 2015 Apr;91:142-7. [3]. Keating GM, et al. Tasimelteon: A Review in Non-24-Hour Sleep-Wake Disorder in Totally Blind Individuals. CNS Drugs. 2016 Mar 22.

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