Promethazine-d4 hydrochloride(Synonyms: 盐酸异丙嗪 d4 (盐酸盐))

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Promethazine-d4 hydrochloride (Synonyms: 盐酸异丙嗪 d4 (盐酸盐))

Promethazine-d4 hydrochloride 是 Promethazine hydrochloride 的氘代物。Promethazine hydrochloride 是一代抗组胺药物，H1 受体强效拮抗剂和 mAChR 拮抗剂，对 5-HT2A、5-HT2C、D2和_alpha_1-adrenergic受体也有一定的亲和性。

Promethazine-d4 hydrochloride(Synonyms: 盐酸异丙嗪 d4 (盐酸盐))

Promethazine-d4 hydrochloride Chemical Structure

CAS No. : 1173018-74-0

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生物活性

Promethazine-d4 hydrochloride is the deuterium labeled Promethazine hydrochloride. Promethazine hydrochloride is the first-generation antihistamine; strong antagonist of the H1 receptor and moderate mACh receptor antagonist, moderate affinity for 5-HT2A, 5-HT2C, D2 and α1-adrenergic receptors.

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

324.90

Formula

C17H17D4ClN2S
CAS 号

1173018-74-0
中文名称

盐酸异丙嗪 d4 (盐酸盐)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Strenkoski-Nix LC, et al. Pharmacokinetics of promethazine hydrochloride after administration of rectal suppositories and oral syrup to healthy subjects. Am J Health Syst Pharm. 2000 Aug 15;57(16):1499-505.

    [3]. Fiorella D, et al. The role of the 5-HT2A and 5-HT2C receptors in the stimulus effects of hallucinogenic drugs. I: Antagonist correlation analysis. Psychopharmacology (Berl). 1995 Oct;121(3):347-56.

    [4]. Seeman P, et al. Dopamine D2 receptor binding sites for agonists. A tetrahedral model. Mol Pharmacol. 1985 Nov;28(5):391-9.

    [5]. Burt DR, et al. Antischizophrenic drugs: chronic treatment elevates dopamine receptor binding in brain. Science. 1977 Apr 15;196(4287):326-8.

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