Torsemide-d7(Synonyms: Torasemide-d7)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Torsemide-d7 (Synonyms: Torasemide-d7)

Torsemide-d7 (Torasemide-d7) 是 Torsemide 的氘代物。Torsemide (Torasemide) 是一种具有口服活性的亨氏环利尿剂。Torsemide 具有抗醛固酮和血管舒张作用。Torsemide 也可用于心力衰竭、肾脏疾病、肝硬化的研究。

Torsemide-d7 Chemical Structure

CAS No. : 1189375-06-1

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生物活性	Torsemide-d7 (Torasemide-d7) is the deuterium labeled Torsemide. Torsemide (Torasemide) is an orally active loop diuretic. Torsemide has anti-aldosterone and vasodilatory effects. Torsemide also can be used for the research of heart failure, renal disease and hepatic cirrhosis^[1]^[1]^[3].
体外研究 (In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	355.46
Formula	C₁₆H₁₃D₇N₄O₃S
CAS 号	1189375-06-1
中文名称	托拉塞米 d7
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Ishido, H., et al. Torasemide for the Treatment of Heart Failure. Cardiovascular & Hematological Disorders-Drug Targets. 2008. 8(2), 127–132. [3]. Goodfriend, T. L., et al. Torsemide inhibits aldosterone secretion in vitro. Life Sciences. 1998. 63(3), PL45–PL50. [4]. H A Friedel, et al. Torasemide. A review of its pharmacological properties and therapeutic potential. Drugs. 1991 Jan;41(1):81-103.

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