1-Stearoyl-2-Arachidonoyl-d8-sn-Glycerol

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1-Stearoyl-2-Arachidonoyl-d8-sn-Glycerol 

1-Stearoyl-2-Arachidonoyl-d8-sn-Glycerol 是 1-Stearoyl-2-arachidonoyl-sn-glycerol 的氘代物。1-Stearoyl-2-arachidonoyl-sn-glycerol 是一种含有多不饱和脂肪酸的二酰基甘油 (DAG)。1-Stearoyl-2-arachidonoyl-sn-glycerol 可以激活 PKC。1-Stearoyl-2-arachidonoyl-sn-glycerol 也可以增强非选择性阳离子通道 (NSCC) 活性。

1-Stearoyl-2-Arachidonoyl-d8-sn-Glycerol

1-Stearoyl-2-Arachidonoyl-d8-sn-Glycerol Chemical Structure

CAS No. : 2692624-31-8

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生物活性

1-Stearoyl-2-Arachidonoyl-d8-sn-Glycerol is the deuterium labeled 1-Stearoyl-2-arachidonoyl-sn-glycerol. 1-Stearoyl-2-arachidonoyl-sn-glycerol is a diacylglycerol (DAG) containing polyunsaturated fatty acids. 1-Stearoyl-2-arachidonoyl-sn-glycerol can activate PKC. 1-Stearoyl-2-arachidonoyl-sn-glycerol also can augment nonselective cation channel (NSCC) activity[1][2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

653.06

Formula

C41H64D8O5
CAS 号

2692624-31-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Song T, et, al. Inositol 1,4,5-trisphosphate activates TRPC3 channels to cause extracellular Ca2+ influx in airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2015 Dec 15;309(12):L1455-66.

    [3]. Madani S, et, al. Implication of acyl chain of diacylglycerols in activation of different isoforms of protein kinase C. FASEB J. 2001 Dec;15(14):2595-601.

    [4]. Glasmacher S, et, al. Characterization of pepcan-23 as pro-peptide of RVD-hemopressin (pepcan-12) and stability of hemopressins in mice. Adv Biol Regul. 2021 May;80:100808.

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