Glutaric acid-d4(Synonyms: 戊二酸 d4)

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Glutaric acid-d4 (Synonyms: 戊二酸 d4)

Glutaric acid-d4 是 Glutaric acid 的氘代物。Glutaric acid，一种 C5 二羧酸，是赖氨酸和色氨酸分解代谢途径中的中间体。Glutaric acid 影响周细胞的收缩性和迁移。Glutaric acid 是 I 型戊二酸尿症的指标。

Glutaric acid-d4(Synonyms: 戊二酸 d4)

Glutaric acid-d4 Chemical Structure

CAS No. : 19136-99-3

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生物活性

Glutaric acid-d4 is the deuterium labeled Glutaric acid. Glutaric acid, C5 dicarboxylic acid, is an intermediate during the catabolic pathways of lysine and tryptophan. Glutaric acid affects pericyte contractility and migration. Glutaric acid is an indicator of glutaric aciduria type I[1][2][3].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

136.14

Formula

C5H4D4O4
CAS 号

19136-99-3
中文名称

戊二酸 d4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Yang SY, et, al. Production of glutaric acid from 5-aminovaleric acid by robust whole-cell immobilized with polyvinyl alcohol and polyethylene glycol. Enzyme Microb Technol. 2019 Sep;128:72-78.

    [3]. Boy N, et, al. Proposed recommendations for diagnosing and managing individuals with glutaric aciduria type I: second revision. J Inherit Metab Dis. 2017 Jan;40(1):75-101.

    [4]. Isasi E, et, al. Glutaric Acid Affects Pericyte Contractility and Migration: Possible Implications for GA-I Pathogenesis. Mol Neurobiol. 2019 Nov;56(11):7694-7707.

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