25-Hydroxycholesterol-d6(Synonyms: 25-羟基胆固醇 d6)

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25-Hydroxycholesterol-d6 (Synonyms: 25-羟基胆固醇 d6)

25-Hydroxycholesterol-d6 是 25-Hydroxycholesterol 的氘代物。25-Hydroxycholesterol 是胆固醇的代谢产物，由巨噬细胞响应 Toll 样受体 (TLR) 激活而产生和分泌。25-Hydroxycholesterol 有效且选择性抑制 B 细胞产生 IgA，EC₅₀ 约为 65 nM。

25-Hydroxycholesterol-d6 Chemical Structure

CAS No. : 88247-69-2

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

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生物活性	25-Hydroxycholesterol-d6 is the deuterium labeled 25-Hydroxycholesterol. 25-Hydroxycholesterol is a metabolite of cholesterol that is produced and secreted by macrophages in response to Toll-like receptor (TLR) activation. 25-hydroxycholesterol is a potent (EC₅₀≈65 nM) and selective suppressor of IgA production by B cells^[1]^[2].
体外研究 (In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	408.69
Formula	C₂₇H₄₀D₆O₂
CAS 号	88247-69-2
中文名称	25-羟基胆固醇 d6
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. McDonald JG, et al. Editorial: 25-Hydroxycholesterol: a new life in immunology. J Leukoc Biol. 2010 Dec;88(6):1071-2.

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