Atenolol-d7(Synonyms: (RS)-Atenolol-d7)

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Atenolol-d7 (Synonyms: (RS)-Atenolol-d7)

Atenolol-d7 ((RS)-Atenolol-d7) 是 Atenolol 的氘代物。Atenolol ((RS)-Atenolol) 是一种心脏选择性的 β1 肾上腺素能受体 (β1-adrenergic receptor) 阻断剂。Atenolol 在豚鼠左心室膜β1肾上腺素能受体处的 Ki 为 697 nM。阿替洛尔可用于高血压和心绞痛的研究。

Atenolol-d7(Synonyms: (RS)-Atenolol-d7)

Atenolol-d7 Chemical Structure

CAS No. : 1202864-50-3

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生物活性

Atenolol-d7 ((RS)-Atenolol-d7) is the deuterium labeled Atenolol. Atenolol ((RS)-Atenolol) is a cardioselective β1-adrenergic receptor blocker, with a Ki of 697 nM atβ1-adrenoceptor in guine pig left ventricle membrane. Atenolol can be used for the research of hypertension and angina pectoris[1][2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

273.38

Formula

C14H15D7N2O3
CAS 号

1202864-50-3
中文名称

阿替洛尔 d7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Heel RC, et al. Atenolol: a review of its pharmacological properties and therapeutic efficacy in angina pectoris and hypertension. Drugs. 1979;17(6):425-460.

    [3]. Engel G, et al. (+/-)[125Iodo] cyanopindolol, a new ligand for beta-adrenoceptors: identification and quantitation of subclasses of beta-adrenoceptors in guinea pig. Naunyn Schmiedebergs Arch Pharmacol. 1981;317(4):277-285.

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