Propranolol-d7 hydrochloride(Synonyms: 盐酸普萘洛尔 d7 (盐酸盐))

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Propranolol-d7 hydrochloride (Synonyms: 盐酸普萘洛尔 d7 (盐酸盐))

Propranolol D7 hydrochloride 是 Propranolol hydrochloride 的氘代物。Propranolol hydrochloride 是一种非选择性的 β-adrenergic receptor (βAR) 拮抗剂，对 β1AR 和 β2AR 具有高亲和力，K_i 值分别为 1.8 nM 和 0.8 nM。Propranolol hydrochloride 抑制 [³H]-DHA 与大鼠脑膜制剂的结合，IC₅₀ 为 12 nM。Propranolol hydrochloride 用于高血压，嗜铬细胞瘤，心肌梗塞，心律不齐，心绞痛和肥大心肌病的相关研究。

Propranolol-d7 hydrochloride Chemical Structure

CAS No. : 1613439-56-7

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生物活性	Propranolol D7 hydrochloride is a deuterium labeled Propranolol hydrochloride. Propranolol hydrochloride is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with K_i values of 1.8 nM and 0.8 nM, respectively^[1]. Propranolol hydrochloride inhibits [³H]-DHA binding to rat brain membrane preparation with an IC₅₀ of 12 nM^[2]. Propranolol hydrochloride is used for the study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy^[3].
IC₅₀ & Target	IC50: 12 nM (βAR)^[1]
分子量	302.85
Formula	C₁₆H₁₅D₇ClNO₂
CAS 号	1613439-56-7
中文名称	盐酸普萘洛尔 d7 (盐酸盐)
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Galandrin S, et al. Distinct signaling profiles of beta1 and beta2 adrenergic receptor ligands toward adenylyl cyclase and mitogen-activated protein kinase reveals the pluridimensionality of efficacy. Mol Pharmacol. 2006 Nov;70(5):1575-84. [2]. Briley M, et al. Evidence against beta-adrenoceptor blocking activity of diltiazem, a drug with calcium antagonist properties. Br J Pharmacol. 1980 Aug;69(4):669-73. [3]. Al-Majed AA, et al. Propranolol. Profiles Drug Subst Excip Relat Methodol. 2017;42:287-338.

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